Endocrine Abstracts

Patients with craniopharyngioma have increased mortality attributed to cardiorespiratory disease, when compared to other hypopituitary populations. There is little data on the cause for excess of fatal respiratory disease in this condition. Clinical observation had identified sleep apnoea in some craniopharyngioma patients in our cohort. Sleep apnoea increases cerebrovascular and cardiovascular morbidity and mortality. Our hypothesis was that sleep apnoea could be a contributo...

Leptin is an adipocytokine with a role in appetite, energy expenditure and reproductive regulation. In normal, non-obese individuals, leptin levels are higher in females, independent of differences in body fat between the genders. High levels of leptin that were disproportionate to body mass index (BMI) have been reported in craniopharyngioma patients, thus we hypothesised that surgical resection and hypothalamic damage conferred leptin resistance on craniopharyngioma patients...

Obesity is a recognised complication of craniopharyngioma (CP), but its aetiology is not understood. Leptin, which signals energy reserve, and ghrelin, which regulates appetite, are implicated in the development of obesity.Our aim was to assess leptin and ghrelin levels in CP patients and to compare these to normal and BMI-matched controls.CP patients were identified from the local database. All CP patients were on hormone replacem...